Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization

Ocular neovascular diseases like wet age-related macular degeneration are a major cause of blindness. Novel therapies are greatly needed for these diseases. One appealing antiangiogenic target is reduction-oxidation factor 1–apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1). This protein can act as...

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Veröffentlicht in:J Pharmacol Exp Ther
Hauptverfasser: Sardar Pasha, Sheik Pran Babu, Sishtla, Kamakshi, Sulaiman, Rania S., Park, Bomina, Shetty, Trupti, Shah, Fenil, Fishel, Melissa L., Wikel, James H., Kelley, Mark R., Corson, Timothy W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2018
Schlagworte:
Cardiovascular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250474/
https://ncbi.nlm.nih.gov/pubmed/30076264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.248088
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