MEF2c-dependent downregulation of Myocilin mediates cancer-induced muscle wasting and associates with cachexia in cancer patients

Skeletal muscle wasting is a devastating consequence of cancer that contributes to increased complications and poor survival, but is not well understood at the molecular level. Herein we investigated the role of Myocilin (Myoc), a skeletal muscle hypertrophy-promoting protein that we showed is downr...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Judge, Sarah M., Deyhle, Michael R., Neyroud, Daria, Nosacka, Rachel L., D’Lugos, Andrew C., Cameron, Miles E., Vohra, Ravneet S., Smuder, Ashley J., Roberts, Brandon M., Callaway, Chandler S., Underwood, Patrick W., Chrzanowski, Stephen M., Batra, Abhinandan, Murphy, Meghan E., Heaven, Jonathan D., Walter, Glenn A., Trevino, Jose G., Judge, Andrew R.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250164/
https://ncbi.nlm.nih.gov/pubmed/32132110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1558
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