CCT020312 Inhibits Triple-Negative Breast Cancer Through PERK Pathway-Mediated G1 Phase Cell Cycle Arrest and Apoptosis

Triple-negative breast cancer (TNBC) has a poor prognosis due to the lack of specific therapeutic targets. CCT020312, a selective eukaryotic translation initiation factor 2 alpha (eIF2α)/protein kinase RNA-like endoplasmic reticulum kinase (PERK) activator, may have a potent anti-tumor effect. In th...

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Udgivet i:Front Pharmacol
Main Authors: Li, Xiaoli, Yu, Xiaoping, Zhou, Duanfang, Chen, Bo, Li, Wenjun, Zheng, Xiangru, Zeng, Hongfang, Long, Liangyuan, Zhou, Weiying
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250150/
https://ncbi.nlm.nih.gov/pubmed/32508655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00737
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