Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease

BACKGROUND: Tubulointerstitial fibrosis represents the key underlying pathology of Chronic Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated the role of connexin43 (Cx43) hemichannel-mediated adenosine triphosphate (ATP) release in purinergic-mediated disasse...

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Опубликовано в: :Cell Commun Signal
Главные авторы: Price, Gareth W., Chadjichristos, Christos E., Kavvadas, Panagiotis, Tang, Sydney C. W., Yiu, Wai Han, Green, Colin R., Potter, Joe A., Siamantouras, Eleftherios, Squires, Paul E., Hills, Claire E.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2020
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7249671/
https://ncbi.nlm.nih.gov/pubmed/32450899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00558-1
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