Mass spectrometry-based stable-isotope tracing uncovers metabolic alterations in pyruvate kinase-deficient Aedes aegypti mosquitoes

A recent in vitro characterization of a recombinant pyruvate kinase (PK) from Aedes aegypti mosquitoes demonstrated that the enzyme is uniquely regulated by multiple allosteric effectors. Here, we further explored PK gene and protein expression, and enzymatic activity in key metabolic tissues of mos...

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Publicat a:Insect Biochem Mol Biol
Autors principals: Petchampai, Natthida, Isoe, Jun, Horvath, Thomas D., Dagan, Shai, Tan, Lin, Lorenzi, Philip L., Hawke, David H., Scaraffia, Patricia Y.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7249512/
https://ncbi.nlm.nih.gov/pubmed/32276114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ibmb.2020.103366
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