Inhibition of transforming growth factor beta signaling pathway promotes differentiation of human induced pluripotent stem cell-derived brain microvascular endothelial-like cells

BACKGROUND: The blood–brain barrier (BBB) plays an important role as a biological barrier by regulating molecular transport between circulating blood and the brain parenchyma. In drug development, the accurate evaluation of BBB permeability is essential to predict not only the efficacy but also the...

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Bibliographic Details
Published in:Fluids Barriers CNS
Main Authors: Yamashita, Misaki, Aoki, Hiromasa, Hashita, Tadahiro, Iwao, Takahiro, Matsunaga, Tamihide
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7249446/
https://ncbi.nlm.nih.gov/pubmed/32456699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-020-00197-1
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