Inhibition of transforming growth factor beta signaling pathway promotes differentiation of human induced pluripotent stem cell-derived brain microvascular endothelial-like cells

BACKGROUND: The blood–brain barrier (BBB) plays an important role as a biological barrier by regulating molecular transport between circulating blood and the brain parenchyma. In drug development, the accurate evaluation of BBB permeability is essential to predict not only the efficacy but also the...

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Detalles Bibliográficos
Publicado en:Fluids Barriers CNS
Main Authors: Yamashita, Misaki, Aoki, Hiromasa, Hashita, Tadahiro, Iwao, Takahiro, Matsunaga, Tamihide
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7249446/
https://ncbi.nlm.nih.gov/pubmed/32456699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-020-00197-1
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