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Personalized and graph genomes reveal missing signal in epigenomic data
BACKGROUND: Epigenomic studies that use next generation sequencing experiments typically rely on the alignment of reads to a reference sequence. However, because of genetic diversity and the diploid nature of the human genome, we hypothesize that using a generic reference could lead to incorrectly m...
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| Publicado no: | Genome Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7249353/ https://ncbi.nlm.nih.gov/pubmed/32450900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02038-8 |
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