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Hypoxia/reoxygenation activates the JNK pathway and accelerates synovial senescence

Hypoxia/reoxygenation (H/R) may play an important role via senescence in the mechanism of osteoarthritis (OA) development. The synovial membrane is highly sensitive to H/R due to its oxygen consumption feature. Excessive mechanical loads and oxidative stress caused by H/R induce a senescence-associa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Med Rep
Prif Awduron: Zhang, Yubiao, Zhou, Siqi, Cai, Weisong, Han, Guangtao, Li, Jianping, Chen, Mao, Li, Haohuan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: D.A. Spandidos 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248463/
https://ncbi.nlm.nih.gov/pubmed/32377698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2020.11102
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