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TYRP1 mRNA level is stable and MITF-M-independent in drug-naïve, vemurafenib- and trametinib-resistant BRAF(V600E) melanoma cells

TYRP1 mRNA is of interest due to its potential non-coding role as a sponge sequestering tumor-suppressive miRs in melanoma. To our knowledge, there is no report on changes in TYRP1 expression in melanomas after development of resistance to targeted therapies. We used patient-derived drug-naïve RAS(Q...

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Detalhes bibliográficos
Publicado no:Arch Dermatol Res
Main Authors: Hartman, Mariusz L., Czyz, Malgorzata
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248034/
https://ncbi.nlm.nih.gov/pubmed/31624899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00403-019-01995-w
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