The RNA helicase DDX6 controls cellular plasticity by modulating P-body homeostasis

Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remain largely unexplored. Here, we show that suppression of the RNA helicase DDX6 endows human and mouse primed embryonic stem cells (ESCs) with a differentiat...

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Publicado no:Cell Stem Cell
Main Authors: Stefano, Bruno Di, Luo, En-Ching, Haggerty, Chuck, Aigner, Stefan, Charlton, Jocelyn, Brumbaugh, Justin, Ji, Fei, Jiménez, Inés Rabano, Clowers, Katie J., Huebner, Aaron J., Clement, Kendell, Lipchina, Inna, de Kort, Marit A. C., Anselmo, Anthony, Pulice, John, Gerli, Mattia F. M., Gu, Hongcang, Gygi, Steven P., Sadreyev, Ruslan I., Meissner, Alexander, Yeo, Gene W., Hochedlinger, Konrad
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247364/
https://ncbi.nlm.nih.gov/pubmed/31588046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.08.018
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