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Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42 and high Aβ43
Familial forms of Alzheimer's disease (FAD) are caused by mutations in the gene encoding amyloid precursor protein, whose processing can result in formation of β-amyloid (Aβ). FAD can also result from mutations in the presenilin 1/2 (PSEN1/2) genes, whose protein products partially compose the...
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| Izdano u: | J Biol Chem |
|---|---|
| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7247318/ https://ncbi.nlm.nih.gov/pubmed/32265300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012542 |
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