Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functions

The mitochondrion of malaria parasites contains several clinically validated drug targets. Within Plasmodium spp., the causative agents of malaria, the mitochondrial DNA (mtDNA) is only 6 kb long, being the smallest mitochondrial genome among all eukaryotes. The mtDNA encodes only three proteins of...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Ling, Liqin, Mulaka, Maruthi, Munro, Justin, Dass, Swati, Mather, Michael W., Riscoe, Michael K., Llinás, Manuel, Zhou, Jing, Ke, Hangjun
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2020
Ämnen:
Metabolism
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247301/
https://ncbi.nlm.nih.gov/pubmed/32273345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012646
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