Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functions

The mitochondrion of malaria parasites contains several clinically validated drug targets. Within Plasmodium spp., the causative agents of malaria, the mitochondrial DNA (mtDNA) is only 6 kb long, being the smallest mitochondrial genome among all eukaryotes. The mtDNA encodes only three proteins of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Ling, Liqin, Mulaka, Maruthi, Munro, Justin, Dass, Swati, Mather, Michael W., Riscoe, Michael K., Llinás, Manuel, Zhou, Jing, Ke, Hangjun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Metabolism
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247301/
https://ncbi.nlm.nih.gov/pubmed/32273345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012646
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