Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functions

The mitochondrion of malaria parasites contains several clinically validated drug targets. Within Plasmodium spp., the causative agents of malaria, the mitochondrial DNA (mtDNA) is only 6 kb long, being the smallest mitochondrial genome among all eukaryotes. The mtDNA encodes only three proteins of...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Ling, Liqin, Mulaka, Maruthi, Munro, Justin, Dass, Swati, Mather, Michael W., Riscoe, Michael K., Llinás, Manuel, Zhou, Jing, Ke, Hangjun
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247301/
https://ncbi.nlm.nih.gov/pubmed/32273345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012646
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