Identification of Lenalidomide Sensitivity and Resistance Mechanisms in Non-Del(5q) Myelodysplastic Syndromes

Whereas lenalidomide is an effective therapy for del(5q) MDS patients, a minority of non-del(5q) MDS patients achieve hematologic improvement with lenalidomide. We used computational biology modeling and digital drug simulation to examine genomic data from 56 non-del(5q) MDS patients treated with le...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Drusbosky, Leylah M., Cogle, Christopher R.
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7246771/
https://ncbi.nlm.nih.gov/pubmed/32397113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21093323
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