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Innate immune responses triggered by nucleic acids inspire the design of immunomodulatory nucleic acid nanoparticles (NANPs)

The unknown immune stimulation by nucleic acid nanoparticles (NANPs) has become one of the major impediments to a broad spectrum of clinical developments of this novel technology. Having evolved to defend against bacterial and viral nucleic acids, mammalian cells have established patterns of recogni...

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Pubblicato in:Curr Opin Biotechnol
Autori principali: Chandler, Morgan, Johnson, M. Brittany, Panigaj, Martin, Afonin, Kirill A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7246180/
https://ncbi.nlm.nih.gov/pubmed/31778882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.copbio.2019.10.011
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