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Characterization of chromatin at structurally abnormal inactive X chromosomes reveals potential evidence of a rare hybrid active and inactive isodicentric X chromosome.

X chromosome structural abnormalities are relatively common in Turner Syndrome patients, in particular X isochromosomes. Reports over the last five decades examining asynchronous DNA replication between the normal X and isochromosome have clearly established that the structurally abnormal chromosome...

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Bibliographic Details
Published in:Chromosome Res
Main Author: Chadwick, Brian P.
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7245565/
https://ncbi.nlm.nih.gov/pubmed/31776830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10577-019-09621-1
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