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Dynamics and Location of the Allosteric Midazolam Site in Cytochrome P4503A4 in Lipid Nanodiscs
Promiscuous and allosteric drug interactions with cytochrome P450 3A4 (CYP3A4) are ubiquitous but incompletely understood at the molecular level. A classic allosteric CYP3A4 drug interaction includes the benzodiazepine midazolam (MDZ). MDZ exhibits homotropic and heterotropic allostery when metaboli...
Shranjeno v:
| izdano v: | Biochemistry |
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| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7245426/ https://ncbi.nlm.nih.gov/pubmed/31961139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b01001 |
| Oznake: |
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