Hydrogen deuterium exchange defines catalytically linked regions of protein flexibility in the catechol O-methyltransferase reaction

Human catechol O-methyltransferase (COMT) has emerged as a model for understanding enzyme-catalyzed methyl transfer from S-adenosylmethionine (AdoMet) to small-molecule catecholate acceptors. Mutation of a single residue (tyrosine 68) behind the methyl-bearing sulfonium of AdoMet was previously show...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zhang, Jianyu, Balsbaugh, Jeremy L., Gao, Shuaihua, Ahn, Natalie G., Klinman, Judith P.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7245127/
https://ncbi.nlm.nih.gov/pubmed/32371482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917219117
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