Apatinib, a Novel Tyrosine Kinase Inhibitor, Promotes ROS-Dependent Apoptosis and Autophagy via the Nrf2/HO-1 Pathway in Ovarian Cancer Cells

Apatinib, a new-generation oral tyrosine kinase inhibitor targeting the vascular endothelial growth factor receptor 2 (VEGFR2) signaling pathway, shows favorable therapeutic effects in various malignant tumors. However, its effect on ovarian cancer has not yet been characterized. Here, we demonstrat...

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Vydáno v:Oxid Med Cell Longev
Hlavní autoři: Sun, Xiaodan, Li, Ji, Li, Yizhuo, Wang, Shouhan, Li, Qingchang
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244982/
https://ncbi.nlm.nih.gov/pubmed/32509141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/3145182
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