SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway

Sirtuin 5 (SIRT5), a mitochondrial class III NAD-dependent deacetylase, plays controversial roles in tumorigenesis and chemoresistance. Accordingly, its role in ovarian cancer development and drug resistance is not fully understood. Here, we demonstrate that SIRT5 is increased in ovarian cancer tiss...

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Vydáno v:Front Oncol
Hlavní autoři: Sun, Xiaodan, Wang, Shouhan, Gai, Junda, Guan, Jingqian, Li, Ji, Li, Yizhuo, Zhao, Jinming, Zhao, Chen, Fu, Lin, Li, Qingchang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700301/
https://ncbi.nlm.nih.gov/pubmed/31456942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00754
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