SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway

Sirtuin 5 (SIRT5), a mitochondrial class III NAD-dependent deacetylase, plays controversial roles in tumorigenesis and chemoresistance. Accordingly, its role in ovarian cancer development and drug resistance is not fully understood. Here, we demonstrate that SIRT5 is increased in ovarian cancer tiss...

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Dettagli Bibliografici
Pubblicato in:Front Oncol
Autori principali: Sun, Xiaodan, Wang, Shouhan, Gai, Junda, Guan, Jingqian, Li, Ji, Li, Yizhuo, Zhao, Jinming, Zhao, Chen, Fu, Lin, Li, Qingchang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700301/
https://ncbi.nlm.nih.gov/pubmed/31456942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00754
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