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Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritis

OBJECTIVES: Identifying blood-based biomarkers that predict treatment response in RA is a clinical priority. We investigated differential DNA methylation as a candidate biomarker of response for the first-line drug used in RA, MTX. METHODS: DNA methylation was measured in DNA samples from individual...

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Detalhes bibliográficos
Publicado no:Rheumatology (Oxford)
Main Authors: Nair, Nisha, Plant, Darren, Verstappen, Suzanne M, Isaacs, John D, Morgan, Ann W, Hyrich, Kimme L, Barton, Anne, Wilson, Anthony G
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244777/
https://ncbi.nlm.nih.gov/pubmed/31598719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/kez411
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