Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis

Anti-Thy1.1 transgenic mice develop glomerular lesions that mimic collapsing focal segmental glomerulosclerosis (FSGS) in humans with collapse of the glomerular tuft and marked hyperplasia of the parietal epithelial cells (PECs). Immunostaining of phosphor-S6 ribosomal protein (pS6RP) revealed high...

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Publicado no:Sci Rep
Main Authors: Miesen, Laura, Eymael, Jennifer, Sharma, Shagun, Loeven, Markus A., Willemsen, Brigith, Bakker-van Bebber, Marinka, Mooren, Fieke, Meyer-Schwesinger, Catherine, Dijkman, Henry, Wetzels, Jack F. M., Jansen, Jitske, van der Vlag, Johan, Smeets, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244565/
https://ncbi.nlm.nih.gov/pubmed/32444668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65352-y
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