Competitive ubiquitination activates the tumor suppressor p53

Blocking p53 ubiquitination through disrupting its interaction with MDM2 or inhibiting the MDM2 catalytic activity is the central mechanism by which the tumor suppressor p53 is activated in response to genotoxic challenges. Although MDM2 is first characterized as the major E3 ubiquitin ligase for p5...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Differ
Prif Awduron: Li, Xingyao, Guo, Mengqi, Cai, Lun, Du, Tingting, Liu, Ying, Ding, Han-Fei, Wang, Hongbo, Zhang, Junran, Chen, Xiaoguang, Yan, Chunhong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244561/
https://ncbi.nlm.nih.gov/pubmed/31796886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0463-x
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