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Competitive ubiquitination activates the tumor suppressor p53
Blocking p53 ubiquitination through disrupting its interaction with MDM2 or inhibiting the MDM2 catalytic activity is the central mechanism by which the tumor suppressor p53 is activated in response to genotoxic challenges. Although MDM2 is first characterized as the major E3 ubiquitin ligase for p5...
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| Vydáno v: | Cell Death Differ |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7244561/ https://ncbi.nlm.nih.gov/pubmed/31796886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0463-x |
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