Competitive ubiquitination activates the tumor suppressor p53

Blocking p53 ubiquitination through disrupting its interaction with MDM2 or inhibiting the MDM2 catalytic activity is the central mechanism by which the tumor suppressor p53 is activated in response to genotoxic challenges. Although MDM2 is first characterized as the major E3 ubiquitin ligase for p5...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Li, Xingyao, Guo, Mengqi, Cai, Lun, Du, Tingting, Liu, Ying, Ding, Han-Fei, Wang, Hongbo, Zhang, Junran, Chen, Xiaoguang, Yan, Chunhong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244561/
https://ncbi.nlm.nih.gov/pubmed/31796886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0463-x
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