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Competitive ubiquitination activates the tumor suppressor p53
Blocking p53 ubiquitination through disrupting its interaction with MDM2 or inhibiting the MDM2 catalytic activity is the central mechanism by which the tumor suppressor p53 is activated in response to genotoxic challenges. Although MDM2 is first characterized as the major E3 ubiquitin ligase for p5...
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| Publicado en: | Cell Death Differ |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7244561/ https://ncbi.nlm.nih.gov/pubmed/31796886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0463-x |
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