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Competitive ubiquitination activates the tumor suppressor p53

Blocking p53 ubiquitination through disrupting its interaction with MDM2 or inhibiting the MDM2 catalytic activity is the central mechanism by which the tumor suppressor p53 is activated in response to genotoxic challenges. Although MDM2 is first characterized as the major E3 ubiquitin ligase for p5...

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Podrobná bibliografie
Vydáno v:Cell Death Differ
Hlavní autoři: Li, Xingyao, Guo, Mengqi, Cai, Lun, Du, Tingting, Liu, Ying, Ding, Han-Fei, Wang, Hongbo, Zhang, Junran, Chen, Xiaoguang, Yan, Chunhong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244561/
https://ncbi.nlm.nih.gov/pubmed/31796886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0463-x
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