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A cysteine selenosulfide redox switch for protein chemical synthesis
The control of cysteine reactivity is of paramount importance for the synthesis of proteins using the native chemical ligation (NCL) reaction. We report that this goal can be achieved in a traceless manner during ligation by appending a simple N-selenoethyl group to cysteine. While in synthetic orga...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7244499/ https://ncbi.nlm.nih.gov/pubmed/32444769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16359-6 |
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