Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist

The development of MET receptor agonists is an important goal in regenerative medicine, but is limited by the complexity and incomplete understanding of its interaction with HGF/SF (Hepatocyte Growth Factor/Scatter Factor). NK1 is a natural occurring agonist comprising the N-terminal (N) and the fir...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Simonneau, Claire, Bérénice Leclercq, Mougel, Alexandra, Adriaenssens, Eric, Paquet, Charlotte, Raibaut, Laurent, Ollivier, Nathalie, Drobecq, Hervé, Marcoux, Julien, Cianférani, Sarah, Tulasne, David, de Jonge, Hugo, Melnyk, Oleg, Vicogne, Jérôme
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2015
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496502/
https://ncbi.nlm.nih.gov/pubmed/28717459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc03856h
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