Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC

An intrinsically disordered neuronal protein α-synuclein (αSyn) is known to cause mitochondrial dysfunction, contributing to loss of dopaminergic neurons in Parkinson’s disease. Through yet poorly defined mechanisms, αSyn crosses mitochondrial outer membrane and targets respiratory complexes leading...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cell Mol Life Sci
Autori principali: Rovini, Amandine, Gurnev, Philip A., Beilina, Alexandra, Queralt-Martín, María, Rosencrans, William, Cookson, Mark R., Bezrukov, Sergey M., Rostovtseva, Tatiana K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2019
Soggetti:
Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244372/
https://ncbi.nlm.nih.gov/pubmed/31760463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03386-w
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi