Significantly enhancing production of trans-4-hydroxy-l-proline by integrated system engineering in Escherichia coli

Trans-4-hydroxy-l-proline is produced by trans-proline-4-hydroxylase with l-proline through glucose fermentation. Here, we designed a thorough “from A to Z” strategy to significantly improve trans-4-hydroxy-l-proline production. Through rare codon selected evolution, Escherichia coli M1 produced 18....

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Long, Mengfei, Xu, Meijuan, Ma, Zhenfeng, Pan, Xuewei, You, Jiajia, Hu, Mengkai, Shao, Yu, Yang, Taowei, Zhang, Xian, Rao, Zhiming
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244267/
https://ncbi.nlm.nih.gov/pubmed/32494747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba2383
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