Urokinase-Type Plasminogen Activator Protects Cerebral Cortical Neurons from Soluble Aβ-Induced Synaptic Damage

Soluble amyloid β (Aβ)-induced synaptic dysfunction is an early event in the pathogenesis of Alzheimer's disease (AD) that precedes the deposition of insoluble Aβ and correlates with the development of cognitive deficits better than the number of plaques. The mammalian plasminogen activation (P...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Diaz, Ariel, Merino, Paola, Guo, Ji-Dong, Yepes, Manuel A., McCann, Patrick, Katta, Tapasya, Tong, Elise M., Torre, Enrique, Rangaraju, Srikant, Yepes, Manuel
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244203/
https://ncbi.nlm.nih.gov/pubmed/32332118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2804-19.2020
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