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O(2)-Functionalized Methylamine Diazeniumdiolates: Evidence for E⇌Z Equilibration in an Acyclic System

Diazeniumdiolates of structure RHN—N(O)═NOR’ are of interest as prodrug (caged) forms of the bioeffectors nitric oxide (NO) and nitroxyl (HNO). Previous work has focused on examples possessing α-branched R groups, with IPA/NO (R = isopropyl) being the smallest examined to date. To probe the effect o...

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Detalhes bibliográficos
Publicado no:J Org Chem
Main Authors: Biswas, Debanjan, Holland, Ryan J., Deschamps, Jeffrey R., Cao, Zhao, Keefer, Larry K., Saavedra, Joseph E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7243909/
https://ncbi.nlm.nih.gov/pubmed/23137026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo3020837
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