Computational Insights Into Voltage Dependence of Polyamine Block in a Strong Inwardly Rectifying K(+) Channel

Inwardly rectifying potassium (K(IR)) channels play important roles in controlling cellular excitability and K(+) ion homeostasis. Under physiological conditions, K(IR) channels allow large K(+) influx at potentials negative to the equilibrium potential of K(+) but permit little outward current at p...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Chen, Xingyu, Bründl, Michael, Friesacher, Theres, Stary-Weinzinger, Anna
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7243266/
https://ncbi.nlm.nih.gov/pubmed/32499707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00721
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