Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes an...

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Publicat a:Cell
Autors principals: Kitchen, Philip, Salman, Mootaz M., Halsey, Andrea M., Clarke-Bland, Charlotte, MacDonald, Justin A., Ishida, Hiroaki, Vogel, Hans J., Almutiri, Sharif, Logan, Ann, Kreida, Stefan, Al-Jubair, Tamim, Winkel Missel, Julie, Gourdon, Pontus, Törnroth-Horsefield, Susanna, Conner, Matthew T., Ahmed, Zubair, Conner, Alex C., Bill, Roslyn M.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242911/
https://ncbi.nlm.nih.gov/pubmed/32413299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.03.037
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