Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice

The etiology and pathogenesis of Parkinson’s disease (PD) are tightly linked to the gain-of-function of α-synuclein. However, gradual accumulation of α-synuclein aggregates in dopaminergic neurons of substantia nigra pars compacta (SNpc) leads to the depletion of the functional pool of soluble α-syn...

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Publicado en:Neurobiol Aging
Autores principales: Ninkina, Natalia, Tarasova, Tatiana V., Chaprov, Kirill D., Roman, Andrei Yu, Kukharsky, Michail S., Kolik, Larisa G., Ovchinnikov, Ruslan, Ustyugov, Aleksey A., Durnev, Andrey D., Buchman, Vladimir L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242904/
https://ncbi.nlm.nih.gov/pubmed/32224067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2020.02.026
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