An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson’s Disease and G2019S LRRK2 Cohorts

The phosphorylated form of LRRK2, pS935 LRRK2, has been proposed as a target modulation biomarker for LRRK2 inhibitors. The primary aim of the study was to characterize and qualify this biomarker for therapeutic trials of LRRK2 inhibitors in Parkinson’s disease (PD). To this end, analytically valida...

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Bibliografske podrobnosti
izdano v:J Parkinsons Dis
Main Authors: Padmanabhan, Shalini, Lanz, Thomas A., Gorman, Donal, Wolfe, Michele, Joyce, Alison, Cabrera, Carlos, Lawrence-Henderson, Rosemary, Levers, Najah, Joshi, Neal, Ma, Thong C., Liong, Christopher, Narayan, Sushma, Alcalay, Roy N., Hutten, Samantha J., Baptista, Marco A.S., Merchant, Kalpana
Format: Artigo
Jezik:Inglês
Izdano: IOS Press 2020
Teme:
Research Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242833/
https://ncbi.nlm.nih.gov/pubmed/32007961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JPD-191786
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