Cotranslational folding stimulates programmed ribosomal frameshifting in the alphavirus structural polyprotein

Viruses maximize their genetic coding capacity through a variety of biochemical mechanisms, including programmed ribosomal frameshifting (PRF), which facilitates the production of multiple proteins from a single mRNA transcript. PRF is typically stimulated by structural elements within the mRNA that...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Harrington, Haley R., Zimmer, Matthew H., Chamness, Laura M., Nash, Veronica, Penn, Wesley D., Miller, Thomas F., Mukhopadhyay, Suchetana, Schlebach, Jonathan P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242702/
https://ncbi.nlm.nih.gov/pubmed/32169904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012706
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