The Melatonin Receptor Agonist Ramelteon Induces Cardioprotection that Requires MT2 Receptor Activation and Release of Reactive Oxygen Species

PURPOSE: The melatonin receptor (MT) agonist ramelteon has a higher affinity to MT1 than for MT2 receptors and induces cardioprotection by involvement of mitochondrial potassium channels. Activation of mitochondrial potassium channels leads to release of free radicals. We investigated whether (1) ra...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cardiovasc Drugs Ther
Prif Awduron: Stroethoff, Martin, Goetze, Lukas, Torregroza, Carolin, Bunte, Sebastian, Raupach, Annika, Heinen, André, Mathes, Alexander, Hollmann, Markus W., Huhn, Ragnar
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer US 2020
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242242/
https://ncbi.nlm.nih.gov/pubmed/32236860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10557-020-06972-4
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