The Melatonin Receptor Agonist Ramelteon Induces Cardioprotection that Requires MT2 Receptor Activation and Release of Reactive Oxygen Species

PURPOSE: The melatonin receptor (MT) agonist ramelteon has a higher affinity to MT1 than for MT2 receptors and induces cardioprotection by involvement of mitochondrial potassium channels. Activation of mitochondrial potassium channels leads to release of free radicals. We investigated whether (1) ra...

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Detaylı Bibliyografya
Yayımlandı:Cardiovasc Drugs Ther
Asıl Yazarlar: Stroethoff, Martin, Goetze, Lukas, Torregroza, Carolin, Bunte, Sebastian, Raupach, Annika, Heinen, André, Mathes, Alexander, Hollmann, Markus W., Huhn, Ragnar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer US 2020
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242242/
https://ncbi.nlm.nih.gov/pubmed/32236860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10557-020-06972-4
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