The Melatonin Receptor Agonist Ramelteon Induces Cardioprotection that Requires MT2 Receptor Activation and Release of Reactive Oxygen Species

PURPOSE: The melatonin receptor (MT) agonist ramelteon has a higher affinity to MT1 than for MT2 receptors and induces cardioprotection by involvement of mitochondrial potassium channels. Activation of mitochondrial potassium channels leads to release of free radicals. We investigated whether (1) ra...

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Detalhes bibliográficos
Publicado no:Cardiovasc Drugs Ther
Main Authors: Stroethoff, Martin, Goetze, Lukas, Torregroza, Carolin, Bunte, Sebastian, Raupach, Annika, Heinen, André, Mathes, Alexander, Hollmann, Markus W., Huhn, Ragnar
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242242/
https://ncbi.nlm.nih.gov/pubmed/32236860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10557-020-06972-4
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