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Activation of PKG and Akt Is Required for Cardioprotection by Ramelteon-Induced Preconditioning and Is Located Upstream of mKCa-Channels
Ramelteon is a Melatonin 1 (MT1)—and Melatonin 2 (MT2)—receptor agonist conferring cardioprotection by pharmacologic preconditioning. While activation of mitochondrial calcium-sensitive potassium (mK(Ca))-channels is involved in this protective mechanism, the specific upstream signaling pathway of R...
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| Izdano u: | Int J Mol Sci |
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| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
MDPI
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7177737/ https://ncbi.nlm.nih.gov/pubmed/32276406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21072585 |
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