The TLR9 Agonist Cobitolimod Induces IL10-Producing Wound Healing Macrophages and Regulatory T Cells in Ulcerative Colitis

BACKGROUND AND AIMS: The topically applied Toll-like receptor 9 [TLR9] agonist cobitolimod is a first-in-class DNA-based oligonucleotide with demonstrated therapeutic efficacy in clinical trials with ulcerative colitis [UC] patients. We here characterized its anti-inflammatory mechanism in UC. METHO...

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Veröffentlicht in:J Crohns Colitis
Hauptverfasser: Schmitt, Heike, Ulmschneider, Julia, Billmeier, Ulrike, Vieth, Michael, Scarozza, Patrizio, Sonnewald, Sophia, Reid, Stephen, Atreya, Imke, Rath, Timo, Zundler, Sebastian, Langheinrich, Melanie, Schüttler, Jürgen, Hartmann, Arndt, Winkler, Thomas, Admyre, Charlotte, Knittel, Thomas, Dieterich Johansson, Christine, Zargari, Arezou, Neurath, Markus F, Atreya, Raja
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242005/
https://ncbi.nlm.nih.gov/pubmed/31630153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ecco-jcc/jjz170
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