Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein

The HIV-1 envelope glycoprotein (Env) mediates viral entry via conformational changes associated with binding the cell surface receptor (CD4) and coreceptor (CCR5/CXCR4), resulting in subsequent fusion of the viral and cellular membranes. While the gp120 Env surface subunit has been extensively stud...

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Dades bibliogràfiques
Publicat a:PLoS Pathog
Autors principals: Joshi, Vinita R., Newman, Ruchi M., Pack, Melissa L., Power, Karen A., Munro, James B., Okawa, Ken, Madani, Navid, Sodroski, Joseph G., Schmidt, Aaron G., Allen, Todd M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241850/
https://ncbi.nlm.nih.gov/pubmed/32392227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008577
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