Pkm2 regulates cardiomyocyte cell cycle and promotes cardiac regeneration

BACKGROUND: The adult mammalian heart has limited regenerative capacity, mostly due to postnatal cardiomyocyte (CM) cell cycle arrest. In the last two decades, numerous studies have explored CM cell cycle regulatory mechanisms to enhance myocardial regeneration post myocardial infarction (MI). Pyruv...

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Published in:Circulation
Main Authors: Magadum, Ajit, Singh, Neha, Kurian, Ann Anu, Munir, Irsa, Mehmood, Talha, Brown, Kemar, Sharkar, Mohammad Tofael Kabir, Chepurko, Elena, Sassi, Yassine, Oh, Jae Gyun, Lee, Philyoung, Santos, Celio XC, Gaziel-Sovran, Avital, Zhang, Guoan, Cai, Chen-Leng, Kho, Changwon, Mayr, Manuel, Shah, Ajay M., Hajjar, Roger J., Zangi, Lior
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241614/
https://ncbi.nlm.nih.gov/pubmed/32078387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.043067
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