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Biochemical mechanism and biological effects of the inhibition of silent information regulator 1 (SIRT1) by EX-527 (SEN0014196 or selisistat)
The human sirtuin silent information regulator 1 (SIRT1) is a NAD(+)-dependent deacetylase enzyme. It deacetylates many protein substrates, including histones and transcription factors, thereby controlling many physiological and pathological processes. Several synthetic inhibitors and activators of...
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| Veröffentlicht in: | J Enzyme Inhib Med Chem |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7241506/ https://ncbi.nlm.nih.gov/pubmed/32366137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1758691 |
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