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Biochemical mechanism and biological effects of the inhibition of silent information regulator 1 (SIRT1) by EX-527 (SEN0014196 or selisistat)

The human sirtuin silent information regulator 1 (SIRT1) is a NAD(+)-dependent deacetylase enzyme. It deacetylates many protein substrates, including histones and transcription factors, thereby controlling many physiological and pathological processes. Several synthetic inhibitors and activators of...

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Publicado en:J Enzyme Inhib Med Chem
Autores principales: Broussy, Sylvain, Laaroussi, Hanna, Vidal, Michel
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241506/
https://ncbi.nlm.nih.gov/pubmed/32366137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1758691
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