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Conserved statin-mediated activation of the p38-MAPK pathway protects Caenorhabditis elegans from the cholesterol-independent effects of statins

OBJECTIVE: Statins are a group of medications that reduce cholesterol synthesis by inhibiting the activity of HMG-CoA reductase, a key enzyme in the mevalonate pathway. The clinical use of statins to lower excess cholesterol levels has revolutionized the cardiovascular field and increased the surviv...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Goncalves, Irina Langier, Tal, Sharon, Barki-Harrington, Liza, Sapir, Amir
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7240216/
https://ncbi.nlm.nih.gov/pubmed/32339771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101003
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