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The UPR(mt) Protects Caenorhabditis elegans from Mitochondrial Dysfunction by Upregulating Specific Enzymes of the Mevalonate Pathway

The mevalonate pathway is the primary target of the cholesterol-lowering drugs statins, some of the most widely prescribed medicines of all time. The pathway’s enzymes not only catalyze the synthesis of cholesterol but also of diverse metabolites such as mitochondrial electron carriers and isoprenyl...

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Foilsithe in:Genetics
Main Authors: Oks, Olga, Lewin, Shany, Goncalves, Irina Langier, Sapir, Amir
Formáid: Artigo
Teanga:Inglês
Foilsithe: Genetics Society of America 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972420/
https://ncbi.nlm.nih.gov/pubmed/29599115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.118.300863
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