Mycobacterium tuberculosis ribosomal protein S1 (RpsA) and variants with truncated C-terminal end show absence of interaction with pyrazinoic acid

Pyrazinamide (PZA) is an antibiotic used in first- and second-line tuberculosis treatment regimens. Approximately 50% of multidrug-resistant tuberculosis and over 90% of extensively drug-resistant tuberculosis strains are also PZA resistant. Despite the key role played by PZA, its mechanisms of acti...

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Publicado no:Sci Rep
Main Authors: Vallejos-Sánchez, Katherine, Lopez, Juan M., Antiparra, Ricardo, Toscano, Emily, Saavedra, Harry, Kirwan, Daniela E., Amzel, L. M., Gilman, R. H., Maruenda, Helena, Sheen, Patricia, Zimic, Mirko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239899/
https://ncbi.nlm.nih.gov/pubmed/32433489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65173-z
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