TGF-β1 secreted by pancreatic stellate cells promotes stemness and tumourigenicity in pancreatic cancer cells through L1CAM downregulation

Pancreatic stellate cells (PSCs) secrete high levels of transforming growth factor-β1 (TGF-β1) that contributes to the development of pancreatic ductal adenocarcinoma (PDAC). TGF-β1 modulates the expression of L1 cell adhesion molecule (L1CAM), but its role in tumour progression still remains contro...

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Udgivet i:Oncogene
Main Authors: Cave, Donatella Delle, Di Guida, Martina, Costa, Valerio, Sevillano, Marta, Ferrante, Luigi, Heeschen, Christopher, Corona, Marco, Cucciardi, Antonio, Lonardo, Enza
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239770/
https://ncbi.nlm.nih.gov/pubmed/32291413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1289-1
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