Tumor Neoantigenicity Assessment with CSiN Score Incorporates Clonality and Immunogenicity to Predict Immunotherapy Outcomes

Lack of responsiveness to checkpoint inhibitors is a central problem in the modern era of cancer immunotherapy. Tumor neoantigens are critical targets of the host antitumor immune response and their presence correlates with the efficacy of immunotherapy treatment. Many studies involving assessment o...

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Bibliographic Details
Published in:Sci Immunol
Main Authors: Lu, Tianshi, Wang, Shidan, Xu, Lin, Zhou, Qinbo, Singla, Nirmish, Gao, Jianjun, Manna, Subrata, Pop, Laurentiu, Xie, Zhiqun, Chen, Mingyi, Luke, Jason J., Brugarolas, James, Hannan, Raquibul, Wang, Tao
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239327/
https://ncbi.nlm.nih.gov/pubmed/32086382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaz3199
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