Tumor Neoantigenicity Assessment with CSiN Score Incorporates Clonality and Immunogenicity to Predict Immunotherapy Outcomes

Lack of responsiveness to checkpoint inhibitors is a central problem in the modern era of cancer immunotherapy. Tumor neoantigens are critical targets of the host antitumor immune response and their presence correlates with the efficacy of immunotherapy treatment. Many studies involving assessment o...

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Pubblicato in:Sci Immunol
Autori principali: Lu, Tianshi, Wang, Shidan, Xu, Lin, Zhou, Qinbo, Singla, Nirmish, Gao, Jianjun, Manna, Subrata, Pop, Laurentiu, Xie, Zhiqun, Chen, Mingyi, Luke, Jason J., Brugarolas, James, Hannan, Raquibul, Wang, Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239327/
https://ncbi.nlm.nih.gov/pubmed/32086382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaz3199
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