Label-Free and Direct Visualization of Multivalent Binding of Bone Morphogenetic Protein-2 with Cartilage Oligomeric Matrix Protein

This work presents the first direct evidence of multivalent binding between bone morphogenetic protein-2 (BMP-2) and cartilage oligomeric matrix protein (COMP) using high-resolution atomic force microscopy (AFM) imaging. AFM topographic images reveal the molecular morphology of COMP, a pentameric pr...

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Bibliografische gegevens
Gepubliceerd in:J Phys Chem B
Hoofdauteurs: Tran, Victoria, Karsai, Arpad, Fong, Michael C., Cai, Weiliang, Yik, Jasper H.N., Klineberg, Eric, Haudenschild, Dominik R., Liu, Gang-yu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7238435/
https://ncbi.nlm.nih.gov/pubmed/30554512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.8b08564
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