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Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions

Acamprosate is an anionic drug substance widely used in treating symptoms of alcohol withdrawal. It was recently shown that oral acamprosate absorption is likely due to paracellular transport. In contrast, little is known about the eliminating mechanism clearing acamprosate from the blood in the kid...

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Bibliografiske detaljer
Udgivet i:Pharmaceutics
Main Authors: Antonescu, Irina E., Karlgren, Maria, Pedersen, Maria L., Simoff, Ivailo, Bergström, Christel A. S., Neuhoff, Sibylle, Artursson, Per, Steffansen, Bente, Nielsen, Carsten Uhd
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7238232/
https://ncbi.nlm.nih.gov/pubmed/32344570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12040390
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